Two sample MR report

Telomere_length against aseg global volume SupraTentorial

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0026008	0.1160339	0.9823290
Weighted median	23	-0.1753621	0.0585330	0.0027359
Inverse variance weighted	23	-0.0827786	0.0448916	0.0651880
Simple mode	23	-0.1618468	0.1125684	0.1645740
Weighted mode	23	-0.1908918	0.0830611	0.0314274

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.61492	21	0.1235577
Inverse variance weighted	29.38277	22	0.1342535

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.004923	0.0065581	0.4611765

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001028	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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