Two sample MR report

Telomere_length against aseg global volume SubCortGray

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0295194	0.1200138	0.8080964
Weighted median	23	-0.0607367	0.0577638	0.2930444
Inverse variance weighted	23	-0.0201790	0.0460403	0.6611770
Simple mode	23	-0.1232097	0.1223535	0.3248841
Weighted mode	23	-0.0866327	0.0652178	0.1976753

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.60995	21	0.0803989
Inverse variance weighted	30.90496	22	0.0980768

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030515	0.0067829	0.6574092

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009447	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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