Two sample MR report

Telomere_length against aseg global volume Optic-Chiasm

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0322889	0.1345093	0.8126196
Weighted median	23	0.0583029	0.0564146	0.3013827
Inverse variance weighted	23	0.0514509	0.0513834	0.3166748
Simple mode	23	0.0901509	0.0978629	0.3669403
Weighted mode	23	0.0545396	0.0619469	0.3881455

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.45015	21	0.0114086
Inverse variance weighted	38.49401	22	0.0161158

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011765	0.0076022	0.8784847

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012196	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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