Two sample MR report

Telomere_length against aseg global volume EstimatedTotalIntraCranial

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0860216	0.1379269	0.5395571
Weighted median	23	0.0208617	0.0545536	0.7021589
Inverse variance weighted	23	0.0219957	0.0529775	0.6780035
Simple mode	23	0.1319430	0.1025680	0.2116784
Weighted mode	23	0.0082329	0.0624989	0.8963956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.42978	21	0.0065907
Inverse variance weighted	40.91940	22	0.0084249

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039311	0.0077952	0.6193001

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012496	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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