Two sample MR report

Telomere_length against aseg global volume CSF

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0073059	0.1272753	0.9547673
Weighted median	23	-0.0071237	0.0595249	0.9047403
Inverse variance weighted	23	-0.0103534	0.0485934	0.8312784
Simple mode	23	-0.0518716	0.0938398	0.5859958
Weighted mode	23	-0.0039146	0.0584345	0.9471935

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.42602	21	0.0326088
Inverse variance weighted	34.42712	22	0.0444234

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0001871	0.0071932	0.9794929

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010453	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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