Two sample MR report

Telomere_length against aseg global volume CC-Posterior

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0748042	0.1050824	0.4843840
Weighted median	23	-0.0715588	0.0567145	0.2070434
Inverse variance weighted	23	-0.0513559	0.0401756	0.2011488
Simple mode	23	-0.0767004	0.0865511	0.3851020
Weighted mode	23	-0.0881832	0.0603948	0.1583932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.46692	21	0.3195972
Inverse variance weighted	23.53259	22	0.3721977

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014397	0.005939	0.8108085

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000766	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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