Two sample MR report

Telomere_length against aseg global volume CC-Mid-Posterior

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1238603	0.1278280	0.3435930
Weighted median	23	0.0054656	0.0535236	0.9186651
Inverse variance weighted	23	0.0168344	0.0497555	0.7351060
Simple mode	23	0.0237843	0.0852675	0.7828983
Weighted mode	23	0.0070179	0.0549367	0.8995118

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.72513	21	0.0302588
Inverse variance weighted	36.09322	22	0.0296750

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065713	0.0072245	0.3733606

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010993	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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