Two sample MR report

Telomere_length against aseg global volume CC-Mid-Anterior

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0621732	0.1051708	0.5607203
Weighted median	23	-0.0352971	0.0539416	0.5128807
Inverse variance weighted	23	-0.0209674	0.0408527	0.6077803
Simple mode	23	-0.0509927	0.0943780	0.5944165
Weighted mode	23	-0.0542440	0.0597692	0.3739461

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.50677	21	0.3175649
Inverse variance weighted	24.33238	22	0.3300509

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0051048	0.005944	0.4001375

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007461	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8