Two sample MR report

Telomere_length against aseg global volume CC-Central

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1255570	0.1065679	0.2519008
Weighted median	23	-0.0289375	0.0556126	0.6028256
Inverse variance weighted	23	0.0065423	0.0420890	0.8764753
Simple mode	23	0.0071551	0.0927596	0.9392125
Weighted mode	23	-0.0362908	0.0635448	0.5737163

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.13552	21	0.2865386
Inverse variance weighted	25.82734	22	0.2591690

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073075	0.0060229	0.2384969

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007834	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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