Two sample MR report

Telomere_length against aseg global volume CC-Anterior

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1509347	0.1114738	0.1901318
Weighted median	23	-0.0472520	0.0569630	0.4068090
Inverse variance weighted	23	-0.0274795	0.0440024	0.5322998
Simple mode	23	-0.0587476	0.1031178	0.5746440
Weighted mode	23	-0.0787700	0.0726823	0.2902068

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.40928	21	0.1912712
Inverse variance weighted	28.22972	22	0.1681924

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075802	0.0063003	0.2423074

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008706	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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