Two sample MR report

Telomere_length against aseg global volume Brain-Stem

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0679086	0.1433613	0.6406097
Weighted median	23	-0.0539744	0.0562870	0.3376018
Inverse variance weighted	23	-0.0231585	0.0553512	0.6756602
Simple mode	23	-0.0578055	0.0967458	0.5562753
Weighted mode	23	-0.0444044	0.0581336	0.4530807

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.67837	21	0.0025729
Inverse variance weighted	44.66891	22	0.0029226

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055914	0.0081023	0.4976875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013643	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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