Two sample MR report

Telomere_length against aseg global volume BrainSegNotVentSurf

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0064383	0.1104827	0.9540814
Weighted median	23	-0.1225751	0.0585280	0.0362336
Inverse variance weighted	23	-0.0616348	0.0426293	0.1482239
Simple mode	23	-0.1361238	0.1197187	0.2677590
Weighted mode	23	-0.1739059	0.0872770	0.0588593

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.94238	21	0.2086548
Inverse variance weighted	26.49588	22	0.2310013

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041797	0.0062443	0.510554

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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