Two sample MR report

Telomere_length against aseg global volume BrainSegNotVent

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0174596	0.1157009	0.8814921
Weighted median	23	-0.1290144	0.0604102	0.0327089
Inverse variance weighted	23	-0.0551164	0.0446596	0.2171489
Simple mode	23	-0.1446159	0.1209099	0.2444043
Weighted mode	23	-0.1682091	0.0847975	0.0599113

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.45070	21	0.1278258
Inverse variance weighted	29.07985	22	0.1425951

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0044562	0.0065392	0.5030272

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009422	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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