Two sample MR report

Telomere_length against aseg global volume BrainSeg

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0333578	0.1184921	0.7810680
Weighted median	23	-0.1133173	0.0622944	0.0689021
Inverse variance weighted	23	-0.0578003	0.0459856	0.2087820
Simple mode	23	-0.1068805	0.1235103	0.3961815
Weighted mode	23	-0.1528510	0.0796910	0.0681769

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.83953	21	0.0952605
Inverse variance weighted	30.83207	22	0.0996034

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055971	0.0066969	0.4126914

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010014	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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