Two sample MR report

Telomere_length against aseg global volume 5th-Ventricle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1637575	0.0994051	0.1143642
Weighted median	23	-0.0865541	0.0606992	0.1538825
Inverse variance weighted	23	-0.0397715	0.0388452	0.3059080
Simple mode	23	-0.0897516	0.1018503	0.3877300
Weighted mode	23	-0.1090596	0.0718368	0.1432152

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.99403	21	0.8232515
Inverse variance weighted	16.83012	22	0.7726672

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076127	0.0056182	0.189808

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005418	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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