Two sample MR report

Telomere_length against aseg global volume 4th-Ventricle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1453175	0.1161574	0.2246787
Weighted median	23	0.1250458	0.0606974	0.0393841
Inverse variance weighted	23	0.0500782	0.0451781	0.2676619
Simple mode	23	0.1678552	0.1260341	0.1965527
Weighted mode	23	0.1678552	0.0779401	0.0424882

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.67550	21	0.1220126
Inverse variance weighted	29.75892	22	0.1244427

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058477	0.006565	0.383159

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009521	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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