Two sample MR report

Telomere_length against aseg global volume 3rd-Ventricle

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1464987	0.1285521	0.2672829
Weighted median	23	0.0243002	0.0589469	0.6801647
Inverse variance weighted	23	0.0028668	0.0507731	0.9549723
Simple mode	23	-0.0423341	0.1148542	0.7159569
Weighted mode	23	0.1159118	0.0719630	0.1214976

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.12186	21	0.0273778
Inverse variance weighted	37.58602	22	0.0203801

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.008819	0.0072655	0.2382908

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001139	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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