Two sample MR report

Telomere_length against aseg global intensity non-WM-hypointensities

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1827688	0.0994059	0.0801585
Weighted median	23	0.0378752	0.0546084	0.4879463
Inverse variance weighted	23	0.0087776	0.0388455	0.8212301
Simple mode	23	0.0018350	0.0902035	0.9839535
Weighted mode	23	0.0245162	0.0581997	0.6776646

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.02120	21	0.6476620
Inverse variance weighted	21.63694	22	0.4817294

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.010683	0.0056182	0.0710448

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006572	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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