Two sample MR report

Telomere_length against aseg global intensity WM-hypointensities

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0677392	0.1298748	0.6074250
Weighted median	23	0.0416183	0.0609555	0.4947553
Inverse variance weighted	23	0.0575961	0.0508657	0.2575011
Simple mode	23	0.0558394	0.1066600	0.6058415
Weighted mode	23	0.0350974	0.0732226	0.6364377

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.84678	21	0.0227475
Inverse variance weighted	37.72304	22	0.0196766

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0076956	0.0073403	0.3063673

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012095	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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