Two sample MR report

Telomere_length against aseg global intensity Optic-Chiasm

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0046448	0.0994066	0.9631739
Weighted median	23	0.0612253	0.0529274	0.2473631
Inverse variance weighted	23	0.0622058	0.0388455	0.1092959
Simple mode	23	0.0198423	0.0867520	0.8211961
Weighted mode	23	0.0367179	0.0629802	0.5658176

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	14.72209	21	0.8366338
Inverse variance weighted	15.25585	22	0.8510261

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0041046	0.0056182	0.473104

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.00054	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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