Two sample MR report

Telomere_length against aseg global intensity CSF

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0479834	0.1385442	0.7325333
Weighted median	23	0.0129635	0.0607283	0.8309631
Inverse variance weighted	23	0.0468373	0.0535866	0.3820919
Simple mode	23	0.1342965	0.1182382	0.2682572
Weighted mode	23	-0.0367149	0.0755272	0.6316932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.79304	21	0.0059469
Inverse variance weighted	41.86693	22	0.0064869

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0058219	0.0078301	0.4653998

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013126	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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