Two sample MR report

Telomere_length against aseg global intensity CC-Posterior

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1319767	0.1189956	0.2799318
Weighted median	23	-0.1041339	0.0582514	0.0738304
Inverse variance weighted	23	-0.0434291	0.0461330	0.3465052
Simple mode	23	-0.0121613	0.1080485	0.9114050
Weighted mode	23	-0.1081798	0.0741490	0.1587099

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.09326	21	0.0901299
Inverse variance weighted	31.02976	22	0.0955082

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0054368	0.0067254	0.4279211

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009781	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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