Two sample MR report

Telomere_length against aseg global intensity CC-Mid-Posterior

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0265065	0.1302224	0.8406661
Weighted median	23	-0.0283503	0.0576645	0.6229723
Inverse variance weighted	23	-0.0525715	0.0502307	0.2952839
Simple mode	23	-0.0535293	0.0955996	0.5811827
Weighted mode	23	-0.0576726	0.0645688	0.3814192

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.04025	21	0.0216387
Inverse variance weighted	36.78717	22	0.0249594

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048554	0.0073599	0.5166099

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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