Two sample MR report

Telomere_length against aseg global intensity CC-Mid-Anterior

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1243451	0.1162538	0.2969402
Weighted median	23	0.0230738	0.0643906	0.7200884
Inverse variance weighted	23	0.0334111	0.0466250	0.4736256
Simple mode	23	0.0307937	0.1385391	0.8261505
Weighted mode	23	-0.0914026	0.0800202	0.2656324

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.72284	21	0.1208161
Inverse variance weighted	31.69542	22	0.0827392

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096863	0.0065705	0.1552566

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009828	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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