Two sample MR report

Telomere_length against aseg global intensity CC-Central

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0868055	0.1141080	0.4552751
Weighted median	23	0.0207217	0.0559163	0.7109471
Inverse variance weighted	23	0.0222965	0.0446702	0.6176842
Simple mode	23	0.0917337	0.0942929	0.3411996
Weighted mode	23	0.0401679	0.0602246	0.5117273

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.67088	21	0.1497347
Inverse variance weighted	29.09256	22	0.1422371

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066988	0.0064491	0.3107473

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008915	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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