Two sample MR report

Telomere_length against aseg global intensity CC-Anterior

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0745827	0.0994058	0.4614071
Weighted median	23	0.0111007	0.0529417	0.8339198
Inverse variance weighted	23	0.0214400	0.0388455	0.5809955
Simple mode	23	-0.0523814	0.0843804	0.5411248
Weighted mode	23	-0.0100239	0.0624248	0.8738926

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.55997	21	0.7374101
Inverse variance weighted	16.89728	22	0.7690055

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032629	0.0056182	0.5675671

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005213	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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