Two sample MR report

Telomere_length against aseg global intensity Brain-Stem

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1119220	0.1171220	0.3501459
Weighted median	23	-0.0957122	0.0616032	0.1202583
Inverse variance weighted	23	-0.1090325	0.0447168	0.0147570
Simple mode	23	-0.1233177	0.1160259	0.2993800
Weighted mode	23	-0.0681707	0.0784536	0.3942666

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.15329	21	0.1103696
Inverse variance weighted	29.15429	22	0.1405083

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001774	0.0066195	0.9788713

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011221	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8