Two sample MR report

Telomere_length against aseg global intensity 5th-Ventricle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1387103	0.0994056	0.1774785
Weighted median	23	-0.0670639	0.0552976	0.2252139
Inverse variance weighted	23	-0.0304142	0.0388453	0.4336516
Simple mode	23	-0.0767748	0.0952909	0.4290455
Weighted mode	23	-0.0810630	0.0704321	0.2621135

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.17990	21	0.9346332
Inverse variance weighted	13.58068	22	0.9156914

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0066494	0.0056182	0.2498188

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004301	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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