Two sample MR report

Telomere_length against aseg global intensity 4th-Ventricle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1995523	0.1282520	0.1346655
Weighted median	23	-0.0848718	0.0654588	0.1947799
Inverse variance weighted	23	-0.0268429	0.0514001	0.6015081
Simple mode	23	-0.1817491	0.1324030	0.1836796
Weighted mode	23	-0.1376312	0.0993252	0.1797380

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.95777	21	0.0285378
Inverse variance weighted	38.52059	22	0.0160044

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0106044	0.0072485	0.1582832

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011817	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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