Two sample MR report

Telomere_length against aseg global intensity 3rd-Ventricle

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0994942	0.1204119	0.4179337
Weighted median	23	-0.0031460	0.0609283	0.9588200
Inverse variance weighted	23	0.0143559	0.0471131	0.7605852
Simple mode	23	0.0741555	0.1104133	0.5088190
Weighted mode	23	-0.0797926	0.0764285	0.3078147

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.81407	21	0.0768084
Inverse variance weighted	32.36226	22	0.0714262

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069904	0.0068054	0.316022

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009847	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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