Two sample MR report

Telomere_length against aparc-pial rh area transversetemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2782507	0.0994070	0.0107512
Weighted median	23	-0.0768895	0.0560613	0.1702109
Inverse variance weighted	23	-0.0278977	0.0429690	0.5161759
Simple mode	23	-0.0994260	0.0862087	0.2611569
Weighted mode	23	-0.1057222	0.0568928	0.0765635

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.43227	21	0.5574313
Inverse variance weighted	26.91807	22	0.2143548

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0153716	0.0056183	0.0123786

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008313	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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