Two sample MR report

Telomere_length against aparc-pial rh area supramarginal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0082595	0.1378072	0.9527737
Weighted median	23	-0.0851656	0.0598225	0.1545511
Inverse variance weighted	23	-0.0500015	0.0528769	0.3443422
Simple mode	23	-0.0825658	0.1028996	0.4309094
Weighted mode	23	-0.0865846	0.0761328	0.2676557

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.35965	21	0.0067223
Inverse variance weighted	40.76507	22	0.0087878

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035772	0.0077885	0.6507434

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012854	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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