Two sample MR report

Telomere_length against aparc-pial rh area superiortemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0196478	0.1133364	0.8640298
Weighted median	23	-0.0660054	0.0548636	0.2289445
Inverse variance weighted	23	-0.0587755	0.0438489	0.1801117
Simple mode	23	-0.0973216	0.0952647	0.3180776
Weighted mode	23	-0.0668888	0.0582479	0.2631589

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.29811	21	0.1612023
Inverse variance weighted	28.03268	22	0.1746009

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0048151	0.0064055	0.4605597

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009188	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8