Two sample MR report

Telomere_length against aparc-pial rh area superiorparietal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0355337	0.1043773	0.7369107
Weighted median	23	0.0063590	0.0551369	0.9081821
Inverse variance weighted	23	-0.0165956	0.0401284	0.6791954
Simple mode	23	0.0657830	0.1140140	0.5698154
Weighted mode	23	0.0565072	0.0678451	0.4138603

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.15277	21	0.3358873
Inverse variance weighted	23.47734	22	0.3752096

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0032007	0.0058992	0.5931362

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007169	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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