Two sample MR report

Telomere_length against aparc-pial rh area superiorfrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0738905	0.1233479	0.5555532
Weighted median	23	-0.0884973	0.0590284	0.1338130
Inverse variance weighted	23	-0.0576955	0.0471157	0.2207450
Simple mode	23	-0.1391929	0.0879849	0.1279187
Weighted mode	23	-0.1199989	0.0723421	0.1113527

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.33419	21	0.0541413
Inverse variance weighted	32.36552	22	0.0713743

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009944	0.0069714	0.8879367

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010476	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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