Two sample MR report

Telomere_length against aparc-pial rh area rostralmiddlefrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0179028	0.1290465	0.8909845
Weighted median	23	-0.0368334	0.0572946	0.5203033
Inverse variance weighted	23	-0.0776124	0.0500217	0.1207639
Simple mode	23	-0.0079716	0.0939781	0.9331683
Weighted mode	23	-0.0591787	0.0668354	0.3854954

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.39120	21	0.0255659
Inverse variance weighted	36.48087	22	0.0269501

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0058646	0.0072934	0.4303496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012263	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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