Two sample MR report

Telomere_length against aparc-pial rh area rostralanteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0082058	0.0994078	0.9349938
Weighted median	23	-0.0352215	0.0545330	0.5183600
Inverse variance weighted	23	-0.0234558	0.0388460	0.5459659
Simple mode	23	-0.1195543	0.0891139	0.1934143
Weighted mode	23	-0.0471950	0.0596269	0.4371007

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.40408	21	0.7465350
Inverse variance weighted	16.43186	22	0.7938901

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009363	0.0056183	0.8692314

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000509	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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