Two sample MR report

Telomere_length against aparc-pial rh area precuneus

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2611275	0.1258086	0.0504055
Weighted median	23	-0.0790539	0.0607240	0.1929653
Inverse variance weighted	23	-0.0132833	0.0530126	0.8021474
Simple mode	23	-0.0894393	0.1073898	0.4138813
Weighted mode	23	-0.1024156	0.0787175	0.2067032

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.63803	21	0.0396040
Inverse variance weighted	40.97494	22	0.0082978

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0152175	0.0071104	0.0442357

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012449	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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