Two sample MR report

Telomere_length against aparc-pial rh area precentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0222872	0.1049480	0.8338706
Weighted median	23	-0.0110068	0.0535037	0.8370095
Inverse variance weighted	23	-0.0410156	0.0401037	0.3064313
Simple mode	23	-0.0275833	0.0814209	0.7379920
Weighted mode	23	-0.0114562	0.0624241	0.8560692

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.40649	21	0.3226940
Inverse variance weighted	23.44838	22	0.3767928

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0011499	0.0059314	0.8481416

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007443	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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