Two sample MR report

Telomere_length against aparc-pial rh area posteriorcingulate

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1751418	0.1397526	0.2238976
Weighted median	23	-0.0070338	0.0539239	0.8962185
Inverse variance weighted	23	-0.0310009	0.0565239	0.5833787
Simple mode	23	-0.0117439	0.0889559	0.8961687
Weighted mode	23	-0.0024869	0.0601577	0.9673983

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.50633	21	0.0048513
Inverse variance weighted	46.58179	22	0.0016634

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.012657	0.0078984	0.1239877

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014306	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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