Two sample MR report

Telomere_length against aparc-pial rh area postcentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1420737	0.1175962	0.2404201
Weighted median	23	-0.0713071	0.0625942	0.2546206
Inverse variance weighted	23	-0.0882152	0.0451608	0.0507771
Simple mode	23	-0.0423359	0.1114020	0.7075684
Weighted mode	23	-0.0622390	0.0739456	0.4090205

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.38920	21	0.1049666
Inverse variance weighted	29.73566	22	0.1250320

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0033069	0.0066463	0.6239661

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010573	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8