Two sample MR report

Telomere_length against aparc-pial rh area pericalcarine

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0659856	0.1191673	0.5856171
Weighted median	23	-0.0317834	0.0613051	0.6041476
Inverse variance weighted	23	0.0221737	0.0456704	0.6273102
Simple mode	23	-0.1283313	0.1103762	0.2574201
Weighted mode	23	-0.1353967	0.1357678	0.3294786

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.18235	21	0.0883845
Inverse variance weighted	30.41163	22	0.1087980

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026901	0.0067352	0.6936241

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009313	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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