Two sample MR report

Telomere_length against aparc-pial rh area parstriangularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0536866	0.1382333	0.7016468
Weighted median	23	-0.0689994	0.0619433	0.2653169
Inverse variance weighted	23	-0.0381619	0.0527949	0.4697820
Simple mode	23	0.1533095	0.1494988	0.3162762
Weighted mode	23	-0.0723966	0.0721675	0.3266836

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.61050	21	0.0062626
Inverse variance weighted	40.63929	22	0.0090942

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009532	0.0078126	0.904052

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012606	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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