Two sample MR report

Telomere_length against aparc-pial rh area parsorbitalis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0756981	0.1023569	0.4677601
Weighted median	23	0.0513073	0.0578307	0.3749725
Inverse variance weighted	23	0.0051339	0.0395974	0.8968418
Simple mode	23	0.0634726	0.1108128	0.5725944
Weighted mode	23	0.0689917	0.0778319	0.3849790

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.26431	21	0.3844182
Inverse variance weighted	22.85900	22	0.4097276

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0043327	0.0057851	0.4621973

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006932	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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