Two sample MR report

Telomere_length against aparc-pial rh area parsopercularis

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2023761	0.1116100	0.0841134
Weighted median	23	-0.1033521	0.0570704	0.0701473
Inverse variance weighted	23	-0.0824745	0.0439723	0.0607098
Simple mode	23	-0.0720287	0.0908750	0.4364678
Weighted mode	23	-0.1139112	0.0608427	0.0745290

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.47418	21	0.1889426
Inverse variance weighted	28.19135	22	0.1694260

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.007362	0.006308	0.2562547

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009908	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8