Two sample MR report

Telomere_length against aparc-pial rh area parahippocampal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0760817	0.0994067	0.4525747
Weighted median	23	-0.0254993	0.0503834	0.6127830
Inverse variance weighted	23	0.0085275	0.0388457	0.8262428
Simple mode	23	-0.0154677	0.0797970	0.8480815
Weighted mode	23	-0.0178739	0.0598540	0.7680280

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.13807	21	0.8159606
Inverse variance weighted	15.68312	22	0.8312951

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0041478	0.0056182	0.4685167

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8