Two sample MR report

Telomere_length against aparc-pial rh area paracentral

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0192133	0.1144188	0.8682521
Weighted median	23	0.0022728	0.0618135	0.9706694
Inverse variance weighted	23	0.0087997	0.0436942	0.8403913
Simple mode	23	0.0610296	0.1070364	0.5743355
Weighted mode	23	0.0342292	0.0750986	0.6530080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.82223	21	0.1452656
Inverse variance weighted	27.83518	22	0.1812080

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0006394	0.0064667	0.9221753

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8