Two sample MR report

Telomere_length against aparc-pial rh area middletemporal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1341692	0.0994042	0.1914725
Weighted median	23	-0.0073918	0.0584814	0.8994190
Inverse variance weighted	23	-0.0155307	0.0388450	0.6892948
Simple mode	23	0.1391853	0.1077248	0.2097496
Weighted mode	23	-0.0080758	0.0940084	0.9323193

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.63346	21	0.8848229
Inverse variance weighted	15.31462	22	0.8483859

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072844	0.0056181	0.2088379

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004689	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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