Two sample MR report

Telomere_length against aparc-pial rh area medialorbitofrontal

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0419164	0.1480742	0.7798894
Weighted median	23	-0.1374662	0.0630778	0.0293087
Inverse variance weighted	23	-0.0384511	0.0565346	0.4964199
Simple mode	23	0.1695447	0.1642851	0.3132776
Weighted mode	23	-0.1788048	0.0931577	0.0679998

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.59977	21	0.0010628
Inverse variance weighted	46.60120	22	0.0016537

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002128	0.0083688	0.9799566

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014417	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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