Two sample MR report

Telomere_length against aparc-pial rh area lingual

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1155933	0.1191032	0.3428289
Weighted median	23	0.1199487	0.0603642	0.0469133
Inverse variance weighted	23	0.0128996	0.0469366	0.7834469
Simple mode	23	0.1701194	0.1289033	0.2004897
Weighted mode	23	0.1589545	0.0833065	0.0695182

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.14818	21	0.0890506
Inverse variance weighted	32.12024	22	0.0753691

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0078895	0.0067315	0.2543105

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009767	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8